This ongoing prospective randomized controlled study is evaluating pregnancy rates and successful long-term pregnancies in 400 women treated with CRINONE 8% progesterone vaginal gel versus compounded progesterone intramuscular injections. Patients were randomized to receive CRINONE 8% (n = 105) or IMP (n = 110). Pregnancy rates, implantation rates, and early spontaneous abortion rates were similar in both arms of the study, whereas fewer side effects and greater overall satisfaction were reported by women receiving CRINONE 8%. This study by Brigham and Women’s Hospital is also evaluating patient satisfaction, which is increasingly important given the trend toward patients taking a more active role in deciding their treatment regimens,” stated Robert S. Fertility and Sterility, known as “the red journal,” publishes juried original articles of scientific excellence in clinical and laboratory research relevant to reproductive endocrinology, physiology, immunology, genetics and menopause. Columbia markets CRINONE® 8% (progesterone gel) and PROCHIEVE® 8% (progesterone gel) in the United States for progesterone supplementation as part of an Assisted Reproductive Technology treatment for infertile women with progesterone deficiency and PROCHIEVE 4% (progesterone gel) for the treatment of secondary amenorrhea. read more

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